C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C12N 7/01 (2006.01)
Patent
CA 2246664
The present invention concerns a DNA sequence isolated from the 5' flanking region of a desmin gene located between nucleotides -10000 to -1000 relative to the transcription initiation site, which contains regulatory elements specific to arterial smooth muscle cells. It also provides as expression cassette using such a DNA sequence to control expression of a gene of interest. Finally, the invention relates to a recombinant vector, a viral particle, an eukaryotic host cell, a pharmaceutical composition comprising said expression cassette and their therapeutic or prophylactic use as well as a transgenic animal having incorporated in its genome said expression cassette.
Li Zhenlin
Mericskay Mathias
Paulin Denise
Robic
Universite Paris 7
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