A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2572451
Methods of delivering an agent in a tissue-specific manner, by targeting annexin Al, a derivative of annexin Al, or a binding partner of annexin Al, are described. The methods can be used for detecting, imaging and/or treating neoplasia, angiogenesis or neovasculature, as well as for diagnostics and methods of assessing treatment efficacy. Antibodies to annexin Al are also described, as are methods screening for agents altering annexin Al activity.
La présente invention se rapporte à des méthodes permettant d'administrer un agent en fonction du type de tissu, par le ciblage de l'annexine A1, d'un dérivé de l'annexine A1, ou d'un partenaire de liaison de l'annexine A1. Les méthodes selon l'invention peuvent servir à détecter, à imager et/ou à traiter la néoplasie, l'angiogenèse ou la croissance néovasculaire, ainsi qu'à diagnostiquer et à évaluer l'efficacité d'un traitement. L'invention concerne aussi des anticorps dirigés contre l'annexine A1, ainsi que des procédés de criblage d'agents modifiant l'activité de l'annexine A1.
Oh Philip
Schnitzer Jan E.
Gowling Lafleur Henderson Llp
Sidney Kimmel Cancer Center
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