Vascularized tissue regeneration matrices formed by solid...

A - Human Necessities – 61 – L

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A61L 27/00 (2006.01) A61F 2/02 (2006.01) A61F 2/10 (2006.01) A61K 35/12 (2006.01) A61K 35/36 (2006.01) A61L 27/38 (2006.01) A61L 27/60 (2006.01) B29C 67/00 (2006.01) A61F 2/00 (2006.01) A61F 2/28 (2006.01) A61F 2/30 (2006.01)

Patent

CA 2222323

Solid free-form fabrication (SFF) methods are used to manufacture devices for allowing tissue regeneration and for seeding and implanting cells to form organ and structural components, which can additionally provide controlled release of bioactive agents, wherein the matrix is characterized by a network of lumens functionally equivalent to the naturally occurring vasculature of the tissue formed by the implanted cells, and which can be lined with endothelial cells and coupled to blood vessels at the time of implantation to form a vascular network throughout the matrix. The SFF methods can be adapted for use with a variety of polymeric, inorganic and composite materials to create structures with defined compositions, strengths, and densities, using computer aided design (CAD). Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three-dimensional printing (3DP).

On utilise des procédés d'élaboration de formes libres solides pour fabriquer des dispositifs qui permettent la régénération de tissus et l'implantation de tissus destinés à former des organes et des éléments structuraux, et qui en outre peuvent libérer de manière réglée des agents bioactifs. La matrice se caractérise par un réseau de conduits de fonction équivalente au système des vaisseaux naturels dans le tissu formé par les cellules implantées. Ce réseau peut être revêtu de cellules endothéliales et couplé aux vaisseaux sanguins au moment de l'implantation afin de former un réseau vasculaire à travers toute la matrice. On peut adapter les procédés d'élaboration de formes libres solides à des matériaux polymères, inorganiques et composites divers afin de créer des structures de composition, résistance et densité définies, en utilisant la conception assistée par ordinateur (CAO). Quelques exemples de procédés d'élaboration de formes libres solides sont la stéréolithographie, le frittage sélectif au laser, la fabrication balistique de particules, le modelage par dépôt et fusion et l'impression tridimensionnelle.

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