Vasculostatic agents and methods of use thereof

Details Vasculostatic agents and methods of use thereof Vasculostatic agents and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 209/04 (2006.01) A61K 31/404 (2006.01) A61K 31/495 (2006.01) C07D 209/14 (2006.01) C07D 209/48 (2006.01) C07D 239/88 (2006.01) C07D 239/90 (2006.01) C07D 239/95 (2006.01) C07D 241/42 (2006.01) C07D 253/10 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2500727

Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.

L'invention concerne des compositions et des procédés destinés au traitement de troubles associés à une vasculostase (conservation du fonctionnement vasculaire homéostatique) fragilisée. Les procédés et compositions selon l'invention sont utiles pour le traitement d'une palette de troubles, notamment un accident vasculaire cérébral, l'infarctus du myocarde, le cancer, l'ischémie/lésion de reperfusion, des maladies auto-immunes, telles que la polyarthrite rhumatoïde, des maladies oculaires, telles que des rétinopathies ou une dégénérescence maculaire ou d'autres maladies vitréo-rétiniennes, des maladies inflammatoires, le syndrome de la fuite vasculaire, l'oedème, le rejet du greffon, le syndrome respiratoire aigu sévère chez l'adulte (SRAS) et analogue.

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