Vasoactive vasotocin derivatives

Details Vasoactive vasotocin derivatives Vasoactive vasotocin derivatives

C - Chemistry, Metallurgy

07

K

C07K 7/16 (2006.01) A61K 38/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2076749

Vasotocin derivatives of formula (I), wherein Hmp = a 2-hydroxy-3- mercaptopropionic acid residue (a), Z = Phe or Tyr, Y = Hgn or Hci, X = (b), Q = H or from 1 to 3 amino acid residues of the same or different natural or unnatural L- or D-amino acids, and n is 1, 2 or 3, are disclosed. A pharmaceutical composition which comprises at least one vasotocin derivative as defined above is intended for use as a vasoconstrictive agent.

On décrit des dérivés de vasotocine de formule (I), où Hmp = un résidu d'acide 2-hydroxy-3-mercaptoproprionique (a); Z = Phe ou Tyr; Y = Hgn ou Hci; X = (b); Q = H ou de 1 à 3 résidus d'acides aminés des mêmes L- ou D-acides aminés naturels ou non naturels, ou différents, et n signifie 1, 2 ou 3. Une composition pharmaceutique comprenant au moins un dérivé de vasotocine selon la description ci-dessus est destinée à une utilisation en tant qu'agent vasoconstricteur.

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