Vasoconstrictive substituted aryloxyalkyl diamines

Details Vasoconstrictive substituted aryloxyalkyl diamines Vasoconstrictive substituted aryloxyalkyl diamines

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) C07D 239/14 (2006.01) C07D 319/18 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 411/12 (2006.01)

Patent

CA 2168023

The present invention is concerned with compounds having formula (I), the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; R3 is C1-6alkyl, hydroxy, cyano halo, C1-6alkyloxy, aryloxy, arylmethoxy, C2-6alkenyl, C2-6alkynyl, C1-6alkyl-S-, C1-6alkyl(S=O)-, C1-6alkylcarbonyl; R4 is hydrogen, halo, hydroxy, C1-6alkyl, or C1-6alkyloxy; or R3 and R4 taken together form a bivalent radical; R5 and R6 each independently are hydrogen, halo hydroxy, C1-6alkyl, C1-6alkyloxy, aryloxy or arylmethoxy; R7 is hydrogen; Alk1 is C2-5alkanediyl; Alk2 is C2-15alkenediyl; Q is a heterocyclic ring containing at least one nitrogen atom or a radical of formula (aa), pharmaceutical compositions, preparations and use as a medicine are described.

La présente invention se rapporte à des composés répondant à la formule (I), à leurs sels d'addition d'acide pharmaceutiquement acceptables et à leurs formes stéréochimiquement isomères; formule dans laquelle R<1> représente hydrogène ou C1-6alkyle; R<2> représente hydrogène ou C1-6alkyle; R<3> représente C1-6alkyle, hydroxy, cyano, halo, C1-6alkyloxy, aryloxy, arylméthoxy, C2-6alcényle, C2-6alcynyle, C1-6alkyl-S-, C1-6alkyl(S=O)-, C1-6alkylcarbonyle; R<4> représente hydrogène, halo, hydroxy, C1-6alkyle ou C1-6alkyloxy; ou R<3> et R<4> forment ensemble un radical bivalent; R<5> et R<6> représentent chacun indépendamment hydrogène, halo, hydroxy, C1-6alkyle, C1-6alkyloxy, aryloxy ou arylméthoxy; R<7> représente hydrogène; Alk<1> représente C2-5alcanediyle; Alk<2> représente C2-15alcanediyle; Q représente un noyau hétérocyclique contenant au moins un atome d'azote ou un radical de la formule (aa). Des compositions pharmaceutiques et des procédés de préparation et d'utilisation de ces compositions comme un médicament sont également décrits.

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