Vasopressin agonist formulation and process

Details Vasopressin agonist formulation and process Vasopressin agonist formulation and process

A - Human Necessities

61

K

A61K 31/5517 (2006.01) A61K 47/00 (2006.01) A61P 7/00 (2006.01)

Patent

CA 2385971

This invention provides novel formulations for vasopressin agonist compounds, or a pharmaceutically acceptable salt thereof, having general structure (I), and processes for making them, the formulations comprising from about 1% to about 20% of active ingredient, from about 1% to about 18% of a surfactant component, from about 50% to about 80% of a component of one or more polyethylene glycols, from about 1% to about 20% of a component of one or more sucrose fatty acid esters and/or polyvinylpyrrolidone and, optionally, one or more preservatives or antioxidants.

L'invention concerne de nouvelles préparations de composés agonistes de la vasopressine, ou d'un sel pharmaceutiquement acceptable de ce composé, présentant la structure générale (I), et leurs procédés de fabrication. Ces préparations comprennent environ 1 % à environ 20 % d'ingrédients actifs, environ 1 % à environ 18 % d'un composant tensio-actif, environ 50 % à environ 80 % d'un composant renfermant un ou plusieurs polyéthylèneglycols, environ 1 % à 20 % d'un composant renfermant un ou plusieurs esters d'acides gras de sucrose et/ou de polyvinylpyrrolidone et, éventuellement, un ou plusieurs conservateurs ou antioxdants.

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