A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/10 (2006.01) A61B 1/00 (2006.01) A61K 51/00 (2006.01) A61M 36/14 (2006.01) A61P 9/12 (2006.01) A61P 9/14 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2501282
Methods and compounds are described for regulating blood pressure in a subject. Specific embodiments are methods for reversing vasodilation of blood vessels, by administering to a subject a therapeutically effective amount peptide AM(11-22). The vasoconstrictor can be used for a variety of purposes, including hemostasis or the treatment of shock, for example vasodilatory shock syndromes such as septic shock. Other specific embodiments are methods for reversing vasoconstriction of blood vessels, by administering to a subject a therapeutically effect amount of an inhibitor of AM(11-22), sufficient to reduce hypertension in the subject. Compounds and pharmaceutical compositions are also provided, as are kits.
La présente invention concerne des procédés et des composés destinés à la régulation de la pression sanguine d'un sujet. Des modes de réalisation spécifiques de l'invention portent sur des procédés permettant d'inverser la vasodilatation des vaisseaux sanguins par administration à un sujet d'une quantité thérapeutiquement suffisante d'un peptide AM(11-22). Le vasoconstricteur peut servir à divers objectifs, y compris l'hémostase ou le traitement du choc, et notamment les syndromes de choc de vasodilatation tels que le choc septique. D'autres modes de réalisation spécifiques de l'invention portent sur des procédés permettant d'inverser la vasoconstriction des vaisseaux sanguins par administration à un sujet d'une quantité thérapeutiquement suffisante d'un peptide AM(11-22), laquelle quantité suffit à réduire l'hypertension chez ce sujet. L'invention concerne également des composés et des compositions pharmaceutiques, ainsi que des nécessaires.
Cuttitta Frank
Martinez Alfredo
Saavedra Juan M.
Stetler-Stevenson William G.
Unsworth Edward J.
Smart & Biggar
The Government Of The United States Of America As Represented By
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