Vdac regulator

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/422 (2006.01) A61K 45/00 (2006.01) A61P 1/00 (2006.01) A61P 1/16 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 7/06 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 19/02 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 25/08 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 31/18 (2006.01) A61P 31/20 (2006

Patent

CA 2479084

The present invention provides a VDAC regulator comprising a compound represented by the formula (I): (see formula I) wherein R1 is a halogen atom, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group or an optionally esterified or amidated carboxyl group; B is an optionally substituted aromatic group; X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom; and Y is a divalent hydrocarbon group or heterocyclic group, a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of Down's syndrome and the like, and the like.

L'invention concerne un régulateur VDAC qui contient un composé représenté par la formule générale (I), (dans laquelle R?1¿ représente halogène, un groupe hétérocyclique éventuellement substitué, hydroxy éventuellement substitué, thiol éventuellement substitué, ou amine éventuellement substitué ; A représente acyle éventuellement substitué, un groupe hétérocyclique éventuellement substitué, hydroxy éventuellement substitué, ou carboxy éventuellement estérifié ou amidifié ; B représente un groupe aromatique éventuellement substitué ; X représente oxygène, soufre, ou azote éventuellement substitué ; et Y représente un groupe hydrocarbure divalent ou un groupe hétérocyclique), un sel de ce composé, ou un promédicament de l'un ou l'autre. Ce régulateur est utilisé comme agent thérapeutique ou préventif du syndrome de Down, etc.

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