Vector comprising gastric protection for oral administration

Details Vector comprising gastric protection for oral administration Vector comprising gastric protection for oral administration

A - Human Necessities

61

K

A61K 38/28 (2006.01) A61K 9/16 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/51 (2006.01) A61K 9/52 (2006.01) A61K 38/00 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2522868

A vector for the oral administration of at least one pharmacologically active substance enabling said active substance to move from the intestinal lumen to the blood, optionally via intersticial liquid, without any substantial degradation of said substance, comprising an essentially hydrophilic matrix having an outer surface which is modified by one or several chemical species providing said vector with an essentially lipophilic quality and containing one or several active substances. The vector is associated with a gastro-resistant vehicle enabling it to pass into the stomach without any denaturation and/or degradation of the active substance. The invention also relates to pharmaceutical compositions containing said vector. Said vectors can be used to produce medicaments used in human or veterinary medicine.

Vecteur pour administration par voie orale d'au moins une substance active sur le plan pharmacologique permettant le passage de ladite substance active de la lumière de l'intestin vers le sang, éventuellement via le liquide interstitiel, sans dégradation substantielle de ladite substance, comprenant une matrice de nature essentiellement hydrophile dont la surface externe est modifiée par une ou plusieurs espèces chimiques conférant audit vecteur une nature essentiellement lipophile, et renfermant une ou plusieurs substances actives. Le vecteur est associé à un véhicule gastro-résistant qui permet le passage dans l'estomac sans dénaturation et/ou dégradation de la substance active Compositions pharmaceutiques contenant ledit vecteur. Utilisation des vecteurs pour la préparation de médicaments en médecine humaine ou vétérinaire.

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