C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/861 (2006.01) A61K 48/00 (2006.01) C07K 14/535 (2006.01) C12N 5/10 (2006.01) C12N 15/27 (2006.01)
Patent
CA 2439185
The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such constructs may be obtained by the insertion of an insulating sequence into a vector construct, such as for example a termination signal sequence upstream of the transcription initiation site of the respective transcription unit.
La présente invention concerne de nouveaux vecteurs viraux et des procédés utilisables pour minimiser l'expression génique partiellement fonctionnelle, et, en particulier, de la translecture transcriptionnelle non spécifique. De telles constructions peuvent être obtenues par l'insertion d'une séquence isolante dans une construction de vecteurs, telle que par exemple un séquence de signaux de terminaison en amont du site d'initiation de la transcription de l'unité de transcription respective. FIG. 6 : A SCHEMA DE STRUCTURE DES VECTEURS AR6pAF ET DE Ar6pAE2fF B PROMOTEUR E2F-1 HUMAIN C INTERMEDIAIRE
Clarke Lori
Gorziglia Mario
Hallenbeck Paul L.
Jakubczak John Leonard
Kaleko Michael
Cell Genesys Inc.
Fetherstonhaugh & Co.
Novartis Ag
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