Vector for liver-specific gene therapy

Details Vector for liver-specific gene therapy Vector for liver-specific gene therapy

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C12N 7/01 (2006.01) C12N 15/64 (2006.01)

Patent

CA 2131415

A tissue specific, suitably liver specific vector for gene therapy of a diseased host, wherein the disease is suitably a diseased liver, comprising an insect virus that contains (i) a therapeutic DNA-sequence, (ii) a promoter for gene expression in the target tissue, suitably the liver tissue of the host, and optionally (iii) an establishment sequence, and processes for its preparation and administration to the host.

Vecteur spécifique à des tissus et suffisamment spécifique au foie pour la thérapie génique d'un hôte malade, où la maladie est, comme il se doit, une hépatopathie, comprenant un virus d'insecte qui contient (i) une séquence d'ADN thérapeutique, (ii) un promoteur favorisant la transcription génique dans le tissu cible, comme il se doit le tissu hépatique de l'hôte, et, de façon facultative, (iii) une séquence d'établissement et des procédés de préparation et d'administration à l'hôte.

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