Vector particles resistant to inactivation by human serum

Details Vector particles resistant to inactivation by human serum Vector particles resistant to inactivation by human serum

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) C07K 14/15 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/40 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2137361

2137361 9325698 PCTABScor01 A retroviral vector particle resistant to inactivation by human serum. The vector particles preferably include p15E protein wherein at least a portion of the DNA encoding p15E protein is mutated such that the vector particle is resistant to inactivation by human serum. The vector particles may further include a protein containing a receptor binding region which binds to the receptor of a human target cell, thereby enabling the direct introduction of desired heterologous genes in vivo, whereby the vector particle including the heterologous gene travels directly to a targeted cell or tissue.

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