C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07K 14/16 (2006.01) C12N 7/06 (2006.01) C12N 15/09 (2006.01) C12N 15/11 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2074188
The present invention relates to viral inhibition, particularly HIV inhibition, by DNA sequences including multiple target response elements. This is the first time that a construct, proposed for gene therapy use, is under the control of a biological regulation. The protective gene product will only be expressed, if the cell becomes infected and a viral protein is made. The DNA construct of the present invention comprises a vector and a promoter operably linked to multiple tat activation response elements so that the elements are transcribed in tandem. The DNA construct can be used in the treatment of viral infections, in particular HIV associated diseases, by obtaining cells from an HIV-infected patient, transforming the cells with the construct and administering the transformed cell to the patient.
Perley-Robertson Hill & Mcdougall Llp
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
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