C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/90 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2244812
The present invention provides elements for producing recombinant nucleic acid molecules and/or recombinant cells. The elements are capable of integrating desired nucleic acid material into other nucleic acid materials, specifically into the genome of a host cell. The elements are derived from or based on transposons, in particular from the Tc/Mariner superfamily. In particular the essential elements of Tc1 enabling excision and pasting of the desired nucleic acid material are provided, together with the relevant transposase activity in cis or in trans.
L'invention concerne des éléments permettant de produire des molécules d'acide nucléique de recombinaison et/ou des cellules de recombinaison. Ces éléments sont capables d'intégrer un acide nucléique désiré dans d'autres acides nucléiques, notamment dans le génome d'une cellule hôte. Ces éléments sont dérivés ou bien sont à base de transposons, appartenant, en particulier, à la super-famille de Tc/Mariner. L'invention, qui concerne, tout spécialement, les éléments essentiels de Tc1 rendant possible une excision et une insertion de l'acide nucléique désiré, porte également sur l'activité correspondante de la transposase en cis ou en trans.
Plasterk Ronald Hans Anton
Vos Jan Christiaan
Borden Ladner Gervais Llp
Het Nederlands Kanker Instituut
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