C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 9/02 (2006.01) C12N 15/12 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2320513
The present invention provides a method of in vitro propagation of a viral eukaryotic gene transfer vector comprising a deleterious, i.e., a cytostatic, cytotoxic, or apoptotic, gene in a eukaryotic, e.g., a mammalian, host- production cell, comprising a blocking gene. The blocking gene inhibits the adverse effects of the deleterious gene on the eukaryotic host-production cell. Vectors and cells useful in the context of the present inventive method are also provided.
La présente invention concerne un procédé de propagation in vitro d'un vecteur de transfert génique eucaryote viral comprenant un gène délétère, c'est-à-dire cytostatique, cytotoxique, ou apoptotique dans une cellule hôte eucaryote, par exemple, une cellule de mammifère, comprenant un gène bloquant. Ce gène bloquant inhibe les effets indésirables du gène délétère sur la cellule hôte eucaryote. L'invention concerne également des vecteurs et des cellules utiles dans le cadre du procédé de la présente invention.
Bruder Joseph T.
Kovesdi Imre
Lizonova Alena
Genvec Inc.
Ridout & Maybee Llp
LandOfFree
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