C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 195/1.22
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01)
Patent
CA 1340221
The present invention comprises novel recombinant DNA compounds which encode the ~40,000 dalton adenocarcinoma antigen recognized by monoclonal antibody KS 1/4. Eukaryotic and prokaryotic expression vectors have been constructed that comprise novel KSA-encoding DNA and drive expression of KSA when transformed into an appropriate host cell. The novel expression vectors can be used to produce KSA derivatives, such as non-glycosylated KSA, and to produce KSA precursors, such as nascent KSA, and to produce subfragments of KSA. The recombinant-produced KSA is useful for the diagnosis, prognosis and treatment of disease states including adenocarcinomas of the lung, prostate, breast, ovary and colon/rectum; and for the creation of novel antibodies for treatment or diagnosis of the above.
589328
Bumol Thomas Frank
Gadski Robert Alan
Hamilton Amy Elizabeth
Sportsman John Richard
Strnad Joann
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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