Vectors for inhibiting hiv and tumor growth

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07K 14/16 (2006.01) C12N 9/22 (2006.01) C12N 15/55 (2006.01) C12N 15/85 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2261987

Cell transformation vectors for inhibiting HIV and tumor growth are provided. Optionally, the vectors encode RNAses such as EDN. Cells transduced by the vectors and methods of transforming cells (in vitro and in vivo) using the vectors are also provided.

La présente invention se rapporte à des vecteurs de transduction cellulaire conçus pour inhiber la croissance du virus de l'immunodéficience humaine et de tumeurs. Lesdits vecteurs peuvent éventuellement coder des ribonucléases du type neurotoxine dérivée d'éosinophiles (EDN eosinophil-derived neurotoxin). L'invention se rapporte également aux cellules transduites par ces vecteurs ainsi qu'à des procédés de transduction de cellules (in vitro et in vivo) faisant usage de ces vecteurs.

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