C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) A61K 31/70 (2006.01) A61K 35/66 (2006.01) A61K 35/74 (2006.01) A61K 48/00 (2006.01) C12N 1/00 (2006.01) C12N 1/36 (2006.01) C12N 15/53 (2006.01) C12N 15/54 (2006.01) C12N 15/55 (2006.01) C12N 15/87 (2006.01) C12Q 1/02 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2224075
The present invention is directed to the isolation and use of super-infective, tumor-specific vectors that are strains of parasites including, but not limited to, bacteria, fungi and protists. In certain embodiments, the parasites include, but are not limited to, the bacterium Salmonella spp., such as Salmonella typhimurium, the bacterium Mycobacterium avium and the protozoan Leishmania amazonensis. In other embodiments, the present invention is concerned with the isolation of super-infective, tumor-specific, suicide gene- containing strains of parasites for use in treatment of solid tumors.
La présente invention se rapporte à l'isolement et à l'utilisation de vecteurs spécifiques de tumeurs et extrêmement infectieux, lesquels sont des souches de parasites comprenant de façon non limitative des bactéries, des champignons et des protistes. Dans certains modes de réalisation, ces parasites comprennent, également de façon non limitative, la bactérie Salmonella spp., telle que Salmonella typhimurium, la bactérie Mycobacterium avium et le protozoaire Leishmania amazonensis. Dans d'autres modes de réalisation, la présente invention concerne l'isolement de souches de parasites, lesquelles sont spécifiques des tumeurs et extrêmement infectieuses, contiennent des gènes suicides et sont utiles dans le traitement de tumeurs solides.
Bermudes David
Low Kenneth B.
Pawelek John M.
Osler Hoskin & Harcourt Llp
Yale University
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