Vectors having terminal repeat sequence of epstein-barr virus

Details Vectors having terminal repeat sequence of epstein-barr virus Vectors having terminal repeat sequence of epstein-barr virus

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A01N 43/04 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 15/38 (2006.01) C12N 15/869 (2006.01) C12N 15/90 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2354844

The use of a unique terminal repeat sequence derived from Epstein-Barr virus to improve the integration frequency of heterologous expression vectors in transfected cells is described. The vectors can be used in a process for deriving high producing cell lines.

La présente invention concerne l'utilisation d'un segment terminal à répétition unique dérivé du virus d'Epstein-Barr, de façon à améliorer la fréquence d'intégration de vecteurs d'expression hétérogènes dans des cellules transfectées. On peut utiliser le vecteur dans un processus destiné à obtenir des lignés de cellules sécrétant un haut niveau de protéines.

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