Vegf activity inhibitors

Details Vegf activity inhibitors Vegf activity inhibitors

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 19/02 (2006.01) A61P 35/04 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2328893

Remedies having an enhanced efficacy against solid tumor, rheumatoid arthritis, diabetic retinopathy, premature retinopathy, psoriasis, etc. comprising a combination of a substance inhibiting signal transduction mediated by a human VEGF receptor Flt-1 with a substance inhibiting signal transduction mediated by a human VEGF receptor KDR, which are useful in diagnosing or treating diseases worsening with abnormal neovascularization, for example, proliferation or metastasis of solid tumor, arthritis in rheumatoid arthritis, diabetic retinopathy, premature retinopathy, psoriasis, etc.

Cette invention porte sur des médicaments à efficacité renforcée contre les tumeurs solides, la polyarthrite rhumatoïde, la rétinopathie diabétique, la rétinopathie prématurée, le psoriasis, etc., renfermant une combinaison d'une substance inhibant la transduction de signal liée à un récepteur Flt-1 du VEGF humain et d'une substance inhibant la transduction de signal liée à un récepteur KDR du VEGF humain. Ces médicaments sont des plus utiles en matière de diagnostic ou de traitement d'une aggravation d'état maladif avec néovascularisation anormale, par exemple prolifération ou métastase de tumeur solide, arthrite dans la polyarthrite rhumatoïde, rétinopathie diabétique, rétinopathie prématurée, psoriasis, etc.

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