Vegf analogs and methods of use

Details Vegf analogs and methods of use Vegf analogs and methods of use

A - Human Necessities

61

K

A61K 38/18 (2006.01) C07K 14/475 (2006.01)

Patent

CA 2625395

Modified VEGF proteins that inhibit VEGF-mediated activation or proliferation of endothelial cells are disclosed. The analogs may be used to inhibit VEGF- mediated activation of endothelial cells in angiogenesis-associated diseases such as cancer, inflammatory diseases, eye diseases, and skin disorders.

L'invention concerne des protéines VEGF modifiées qui inhibent l'activation ou la prolifération induite par VEGF des cellules endothéliales. Ces analogues peuvent être utilisés pour inhiber l'activation induite par VEGF des cellules endothéliales dans le cas de maladies associées à l'angiogenèse, telles que le cancer, les maladies inflammatoires, les maladies oculaires et les troubles cutanés.

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