Vegf-b/receptor complex and uses thereof

Details Vegf-b/receptor complex and uses thereof Vegf-b/receptor complex and uses thereof

G - Physics

01

N

G01N 33/53 (2006.01) A61K 38/18 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01) C07K 14/71 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2274675

Disclosed are complexes of Vascular Endothelial Growth Factor-B (VEGF-B) and the Flt-1 tyrosine kinase receptor; the use of such VEGF-B/Flt-1 complexes in assays for VEGF-B or for VEGF-B analogs characterized as having substantially the same binding affinity for a cell surface receptor as VEGF-B, and/or in promoting or antagonizing a VEGF-B-mediated cell response; and specific binding partners, e.g. antibodies, for such VEGF-B/Flt-1 complexes.

La présente invention concerne d'une part des complexes de facteurs B de croissance de l'endothélium vasculaire (VEGF-B) et le récepteur de la tyrosine kinase Flt-1; d'autre part, l'utilisation desdits complexes VEGF-B/Flt-1 dans des dosages en vue d'identifier le VEGF-B et les analogues de VEGF-B caractérisés par le fait qu'ils ont sensiblement la même affinité de liaison vis-à-vis d'un récepteur de surface cellulaire tel que le VEGF-B, et/ou qu'ils favorisent une réponse cellulaire induite par VEGF-B ou s'opposent à celle-ci; enfin, l'invention concerne les partenaires de liaison spécifiques desdits complexes de VEGF-B/Flt-1, par exemple, des anticorps.

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