Vegf-d and angiogenic use thereof

Details Vegf-d and angiogenic use thereof Vegf-d and angiogenic use thereof

C - Chemistry, Metallurgy

07

K

C07K 14/52 (2006.01) A61K 38/19 (2006.01) A61P 9/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2381985

The present invention is directed to a method of inducing angiogenesis in a tissue in need of angiogenesis, comprising providing the tissue in need of angiogenesis with an angiogenically effective amount of a recombinant c-fos induced growth factor/vascular endothelial growth factor D (Figf/Vegf-D), which is a secreted factor of the VEGF family which binds to the vessel and lymphatic receptors VEGFR-2 and VEGFR-3 (VEGF-D). In another aspect, the present invention is directed to a method of inducing angiogenesis in an area in need of angiogenesis in a mammal comprising administering to said area in need of angiogenesis an angiogenically effective amount VEGF-D. The VEGF-D is provided or administered in solution of slow release form.

L'invention concerne un procédé de production d'angiogénèse dans un tissu qui manque d'angiogénèse, comportant l'apport d'une quantité efficace, sur le plan angiogénique, d'un facteur de croissance produit/facteur de croissance vasculaire endothéliale D recombinant c-fos (Figf/Vegf-D), qui est un facteur secrété de la famille VGF qui se lie aux récepteurs des vaisseaux et lymphatiques VEGFR-2 et VEGFR-3 (VEGF-D), au tissu en manque d'angiogénèse. Dans un autre aspect de la présente invention, un procédé de production d'angiogénèse est proposé pour une région qui manque d'angiogénèse chez un mammifère. Ce procédé consiste à administrer à ladite région en manque d'angiogénèse, une quantité efficace, sur le plan angiogénique, de VEGF-D. Ce VEGF-D est fourni ou administré sous forme de solution à diffusion lente.

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