Vegf receptor fusion protein and use thereof

Details Vegf receptor fusion protein and use thereof Vegf receptor fusion protein and use thereof

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61P 27/02 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2647142

Vascular endothelial growth factor (VEGF) receptor fusion protein comprising Ig domain 2 of Flt-1 and Ig domains 3, or Ig domain 2 of Flt-1 and Ig domains 3 and 4 of KDR, the gene encoding the fusion protein, the pharmaceutical composition containing the fusion protein and the pharmaceutical use of the fusion protein are provided. The fusion protein can be used for treatment of eye disorders involving angiogenesis such as diabetic retinopathy.

L'invention concerne une protéine de fusion du récepteur du facteur de croissance endothéliale (VEGF) comprenant le domaine lg 2 de Flt-1 et des domaines lg 3, ou le domaine lg 2 de Flt-1 et des domaines lg 3 et 4 de KDR, le gène codant la protéine de fusion, la composition pharmaceutique comprenant la protéine de fusion et l'utilisation pharmaceutique de la protéine de fusion. La protéine de fusion peut s'utiliser dans le traitement de troubles de l'oeil à angiogenèsse tels que la rétinopathie diabétique.

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