C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) C07K 5/083 (2006.01) C07K 19/00 (2006.01) C07K 14/71 (2006.01)
Patent
CA 2695960
The present invention concerns the fields of molecular medicine and targeted delivery of therapeutic agents. More specifically, the present invention relates to the identification of novel peptide sequences that incorporate the amino acids Leu-Pro-Arg (LPR), and particularly D(LPR), that selectively target VEGFR-1 and NRP-1 expressing cells. Targeted molecules in accordance with the invention are useful in the treatment and detection of neovascular or angiogenic VEGF associated disorders, including but not limited to cancer, obesity, diabetes, asthma, arthritis, cirrhosis and ocular diseases.
La présente invention concerne les domaines de la médecine moléculaire et de l'administration ciblée d'agents thérapeutiques. Plus précisément, la présente invention concerne l'identification de séquences peptidiques inédites incorporant les acides aminés Leu-Pro-Arg (LPR) et particulièrement D(LPR), qui ciblent, de façon sélective, des cellules exprimant VEGFR-I et NRP-I. Les molécules ciblées conformément à l'invention sont utilisables dans le cadre du traitement et de la détection d'affections néovasculaires ou angiogéniques associées au VEGF, dont, mais la liste n'est pas limitative, le cancer, l'obésité, le diabète, l'asthme, l'arthrite, la cirrhose et les maladies oculaires.
Arap Wadih
Cardo-Vila Marina
Ceneviva Lacerda de Almeida Fabio
Giordano Ricardo
Pasqualini Renata
Gowling Lafleur Henderson Llp
The Board Of Regents Of The University Of Texas System
Universidade Federal Do Rio de Janeiro
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