Vegfr-3 binding peptides and their use for inhibiting...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61P 35/00 (2006.01) C07K 14/52 (2006.01) C07K 14/71 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2450929

The present invention relates to the diagnostics, evaluation, and therapeutic intervention of disorders mediated by the activity of cell surface receptor VEGFR-3, which activity often is stimulated by VEGFR-3 ligands VEGF-C and VEGF- D. More particularly, the present invention identifies novel methods and compositions for the inhibition of VEGF-C/D binding to VEGFR-3. The compositions of the present invention will be useful the inhibition of angiogenesis and lymphangiogenesis.

L'invention porte sur des diagnostics, des évaluations et des interventions thérapeutiques de troubles induits par l'activité du récepteur de surface cellulaire VEGFR-3, dont l'activité est souvent stimulée par des ligands VEGFR-3, VEGF-C et VEGF-D. Plus précisément, l'invention a trait à l'identification de nouvelles méthodes et compositions d'inhibition de VEGF-C/D lié au VEGFR-3. Ces compositions selon l'invention seront utiles à l'inhibition des angiogenèses et des lymphangiogenèses.

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