Verotoxin pharmaceutical compositions and medical treatments...

A - Human Necessities – 61 – K

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A61K 38/47 (2006.01) A61K 47/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2163716

Pharmaceutical compositions comprising known verotoxins, particularly, verotoxin 1 and their pentameric subunit B, have been found to be useful in the treatment of mammalian neoplasia, particularly, brain cancer, ovarian cancer, breast cancer and skin cancer. Although verotoxin 1 has previously been shown to have anti-neoplastic activity in vitro, non-lethal doses of verotoxin 1 have been shown to be therapeutically anti- neoplastic in vivo. Use of a sensitizer, such as sodium butyrate, enhances the efficacy of verotoxins and their subunit B.

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