Vertebrate embryonic pattern-inducing hedgehog-like proteins

Details Vertebrate embryonic pattern-inducing hedgehog-like proteins Vertebrate embryonic pattern-inducing hedgehog-like proteins

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61P 19/00 (2006.01) A61P 25/28 (2006.01) C07H 21/00 (2006.01) C07K 14/46 (2006.01) C07K 14/475 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01) C12N 15/79 (2006.01) C12N 15/87 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2179029

The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog- related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.

L'invention concerne la découverte que les protéines codées par une famille de gènes de vertébrés, dénommés ici gènes apparentés au hérisson, comprennent des signaux morphogéniques produits par des centres de structuration embryonnaire, et qu'elles sont impliquées dans la formation de dispositions spatiales ordonnées de tissus différenciés de vertébrés. L'invention concerne des compositions et des procédés qui s'utilisent par exemple pour créer et/ou pour maintenir une série de tissus différents de vertébrés, à la fois in vitro et in vivo.

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