Vertebrate fringe proteins

Details Vertebrate fringe proteins Vertebrate fringe proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07K 14/465 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2243081

Isolated DNA encoding a protein or polypeptide having at least one biological activity of a vertebrate fringe protein, as well as the protein or polypeptide encoded thereby, are described. Assays for identifying agents which alter the expression of the described fringe genes and assays for agents which alter the production of angiogenic precursors, the formation of the apical ectodermal ridge and the subdivisions of the neural tube are also described.

L'invention porte sur de l'ADN isolé codant pour une protéine ou un polypeptide présentant au moins une activité biologique d'une protéine frangée de vertébré ainsi que la protéine ou le polypeptide ainsi codé. Elle porte également sur des dosages d'identification d'agents modifiant l'expression des gènes frangés décrits, ainsi que sur des dosages d'identification d'agents agissant sur la production de précurseurs angiogéniques, sur la formation de la crête apicale ectodermique et sur les subdivisions du tube médullaire.

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