Vertebrate homologues of unc-53 protein of c. elegans

Details Vertebrate homologues of unc-53 protein of c. elegans Vertebrate homologues of unc-53 protein of c. elegans

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 49/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2273827

Vertebrate protein homologues of UNC-53 protein of C. elegans and nucleic acid sequences coding for said homologues or functional equivalents thereof are identified. The nucleic acid sequences in an appropriate vector are used to transfect or transform cells, tissues or organisms useful in identifying inhibitors or enhancers of the vertebrate homologue, or further proteins involved in the signal transduction pathway of which said vertebrate homologue is a component. Any of said inhibitors or enhancers identified can be included in a pharmaceutical composition or in the preparation of a medicament for treating conditions such as neurological diseases, acute traumatic injuries and to promote neuronal regeneration and inhibit metastasis or loss of contact inhibition.

L'invention concerne l'identification d'homologues vertébrés de la protéine UNC-53 de C. elegans et des séquences d'acide nucléotidiques codant pour lesdits homologues ou leurs équivalents fonctionnels. Les séquences nucléotidiques sont utilisées dans un vecteur approprié pour transfecter ou transformer des cellules, des tissus ou des organismes utiles pour identifier des inhibiteurs ou des activateurs de l'homologue vertébré ou d'autres protéines impliquées dans la voie de transduction du signal dont ledit homologue vertébré est un élément. N'importe lequel desdits inhibiteurs ou activateurs identifiés peut être inclus dans une composition pharmaceutique ou dans la préparation d'un médicament destiné à traiter des pathologies (maladie neurologique, trauma aigu, par exemple) ou à promouvoir la régénération neuronale ou inhiber la métastase ou la perte de l'inhibition de contact.

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