Vertebrate poxvirus expression vector under the control of...

Details Vertebrate poxvirus expression vector under the control of... Vertebrate poxvirus expression vector under the control of...

C - Chemistry, Metallurgy

12

N

167/130, 195/1.2

C12N 7/01 (2006.01) A61K 39/275 (2006.01) C12N 15/863 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2033957

74066-2 ABSTRACT OF THE DISCLOSURE Disclosed is a recombinant vertebrate poxvirus such as vaccinia virus which comprises in its genome (i) spheroidin promoter of entomopoxvirus such as Choristoneura biennis and (ii) at least one structural gene coding for at least one protein foreign to entomopoxvirus and to the vertebrate poxvirus and is capable of expressing the foreign protein gene in a vertebrate tissue culture cell or in a vertebrate animal susceptible to the vaccinia virus. The recombinant virus is capable of expressing the foreign gene at a significantly higher rate due to the presence of the entomopoxvirus spheroidin promoter than the same virus without the entomopoxvirus promoter. The protein may be antigenic or otherwise pharmaceutically useful. Also disclosed is vaccine and a process for producing the protein using the recom- binant virus.

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