Vesicles of self-assembling block copolymers and methods for...

Details Vesicles of self-assembling block copolymers and methods for... Vesicles of self-assembling block copolymers and methods for...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/51 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2671461

Vesicles of self-assembling block copolymers, e.g., diblock copolypeptides, as well as methods of making and using the same. Vesicles of the invention have a shell made up of block copolymers that include an intracellular transduction hydrophilic domain and a hydrophobic domain. In certain embodiments, the vesicles include an encapsulated active agent, e.g., a diagnostic or therapeutic agent. The vesicles find use in a variety of different application, including the intracellular delivery of active agents, e.g., diagnostic and therapeutic agents.

La présente invention concerne des vésicules de copolymères séquencés à auto-assemblage, par exemple des copolypeptides diséquencés, ainsi que des procédés de réalisation et d'utilisation de ceux-ci. Les vésicules de l'invention présentent une coque faite de copolymères séquencés qui incluent un domaine hydrophile de transduction intracellulaire et un domaine hydrophobe. Dans certains modes de réalisation, les vésicules incluent un agent actif encapsulé, par exemple un agent de diagnostic ou un agent thérapeutique. Lesdites vésicules sont utiles dans une variété d'applications différentes, notamment la fourniture intracellulaire d'agents actifs, tels que des agents de diagnostic et des agents thérapeutiques.

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