Vhz for diagnosis and treatment of cancer

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/44 (2006.01) A61P 35/00 (2006.01) C12N 9/16 (2006.01) C12Q 1/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) C07K 16/40 (2006.01)

Patent

CA 2695981

We provide VHZ for use in a method of treatment, prophylaxis or alleviation of a cancer, such as breast cancer, in an individual. We provide an anti- VHZ agent for the treatment, prophylaxis or alleviation of cancer. We further provide a kit for detecting breast cancer in an individual or susceptibility of the individual to breast cancer comprising means for detection of VHZ expression in the individual or a sample taken from him or her as well as a method of detecting a cancer cell, the method comprising detecting modulation of expression, amount or activity of VHZ in the cell.

La présente invention concerne l'utilisation du VHZ dans un procédé de traitement, de prophylaxie ou d'atténuation d'un cancer chez un individu, tel qu'un cancer de la poitrine. L'invention concerne en particulier un agent anti-VHZ destiné à être utilisé dans le traitement, la prophylaxie ou l'atténuation d'un cancer. L'invention concerne par ailleurs un kit permettant de détecter un cancer de la poitrine ou le risque de développer un tel cancer chez un individu. Ledit kit comprend des moyens de détection de l'expression VHZ chez ledit individu ou dans un échantillon prélevé chez lui, ainsi qu'un procédé de détection d'une cellule cancéreuse. Ledit procédé comprend la détection de la modulation de l'expression du VHZ et la quantité de son activité dans la cellule.

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