C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) A61K 39/106 (2006.01) C07K 14/28 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01) C12N 15/65 (2006.01) C12N 15/74 (2006.01)
Patent
CA 2173606
Avirulent Vibrio cholerae strains of 01 (CVD111) and non-01 (CVD112 and CVD112RM) serogroups having the DNA of the cholera toxin core and the RS1 sequences of the cholera toxin locus deleted, and further having a DNA encoding a resistance to mercury, and a DNA encoding the cholera toxin B subunit, or a part thereof sufficient to confer immunogenicity, re-inserted in the chromosome. Methods of making the avirulent V. cholerae 01 and non-01 strains of the invention, and cholera vaccines using these strains.
Souches de Vibrio cholerae avirulentes des sérogroupes 01 (CVD111) et non 01 (CVD112 et CVD112RM) dont l'ADN du coeur de la toxine cholérique et les séquences RS1 du locus de la toxine cholérique ont été supprimés. Lesdites souches possèdent en outre un ADN codant une résistance au mercure et un ADN codant la sous-unité B de la toxine cholérique, ou une partie dudit ADN suffisante pour conférer l'immunogénicité, réintroduits dans le chromosome. Des procédés de fabrication de souches avirulentes 01 et non 01 du V. cholerae de la présente invention et des vaccins contre le choléra utilisant lesdites souches sont également décrits.
Kaper James B.
Levine Myron M.
Gowling Lafleur Henderson Llp
University Of Maryland At Baltimore
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