Vibrio cholerae lps detoxified derivatives and immunogenic...

Details Vibrio cholerae lps detoxified derivatives and immunogenic... Vibrio cholerae lps detoxified derivatives and immunogenic...

C - Chemistry, Metallurgy

07

K

C07K 16/12 (2006.01) A61K 39/106 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 31/04 (2006.01) C07H 15/12 (2006.01) C07K 16/44 (2006.01) C08B 37/00 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2475736

The presence of a free amino group on the D-glucosamine residue of the detoxified lipopolysaccharide (LPS) of Vibrio cholerae is exploited for the site-specific derivatization of this polysaccharide. The invention allows the preparation of V. cholerae LPS derivatives useful for the immuno-detection. The invention also provides a convenient way to prepare detoxified LPS of V. cholerae (and especially V. cholerae O1, serotype Inaba)-immunogenic carrier conjugates. Thanks to the single modification introduced following the adopted strategy, all derivatives of the detoxified LPS can be fully analyzed in term of purity and identity. This leads to an improved characterization of the conjugates and a better control of their preparation processes.

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