C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2391305
The invention provides methods of identifying compounds that alters vigilance, by contacting an invertebrate with a candidate compound, evaluating a vigilance property in the contacted invertebrate, and determining if the candidate compound alters the vigilance property in the contacted invertebrate. Also provided are isolated vigilance nucleic acid molecules. Methods for diagnosing and treating vigilance disorders, for determining and altering vigilance levels, and for screening for therapeutic compounds useful for treating vigilance disorders and altering vigilance level, are also provided.
Cette invention a trait à des méthodes permettant d'identifier des composés modifiant la vigilance. Ces méthodes consistent à mettre en contact un invertébré avec un composé candidat, à évaluer les caractéristiques de vigilance chez cet invertébré et à déterminer si le composé candidat modifie les caractéristiques de vigilance dudit invertébré. L'invention porte également sur des acides nucléiques en rapport avec la vigilance. Elle concerne, de plus, des méthodes permettant de diagnostiquer et de traiter des troubles de la vigilance, de déterminer et de modifier des niveaux de vigilance ainsi que des techniques de criblage de composés thérapeutiques, des plus utiles en matière de traitement de la vigilance et de modification du niveau de vigilance.
Cirelli Chiara
Greenspan Ralph J.
Shaw Paul J.
Tononi Giulio
Neurosciences Research Foundation Inc.
Smart & Biggar
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