Vimentin directed diagnostics and therapeutics for multidrug...

Details Vimentin directed diagnostics and therapeutics for multidrug... Vimentin directed diagnostics and therapeutics for multidrug...

G - Physics

01

N

G01N 33/567 (2006.01) A61K 39/00 (2006.01) A61K 47/30 (2006.01) A61K 47/42 (2006.01) A61K 49/00 (2006.01) A61K 51/06 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2509987

Disclosed are methods for detecting multidrug resistance in neoplastic or damaged cells or multidrug resistant (MDR) neoplastic or damaged cells by detecting an increase in the cell surface expression of vimentin protein in such cells as compared to the level of cell surface expression of vimentin protein in a normal cell or a non-MDR neoplastic cell.

Ces méthodes permettent de détecter la multirésistance aux médicaments dans des cellules néoplasiques ou endommagées ou de détecter des cellules néoplasiques ou endommagées à multirésistance aux médicaments par détection d'une augmentation de l'expression de la protéine vimentine dans la surface de la cellule par rapport à l'expression de la protéine vimentine dans la surface d'une cellule normale ou néoplasique n'ayant pas une multirésistance aux médicaments.

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