Vinblastine synthesis

Details Vinblastine synthesis Vinblastine synthesis

C - Chemistry, Metallurgy

12

P

195/86

C12P 17/18 (2006.01) C12N 9/02 (2006.01) C12P 1/00 (2006.01)

Patent

CA 1304308

ABSTRACT The reaction of 3',4'-anhydrovinblastine with a Catharanthus roseus-derived protein fraction to form vinblastine is improved by conducting the reaction in the presence of a reducing agent such as the enzyme cofactor NADH. A cationic species such as manganous ion may also be added to the reaction. Vinblastine yields are enhanced.

544979

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