Vinca alkaloid antimitotic halogenated derivatives

Details Vinca alkaloid antimitotic halogenated derivatives Vinca alkaloid antimitotic halogenated derivatives

C - Chemistry, Metallurgy

07

D

C07D 519/04 (2006.01) A61K 31/475 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2665949

Nouveaux dérivés halogénés de la famille de a vinorelbine, correspondant à la formule générale (1) ainsi que leurs sels thérapeutiquement acceptables. L'invention concerne également l'application des ces composés en thérapeutique et les procédés de préparation. L'invention a également pour objet un nouveau procédé de préparation de la vinflunine ou 20',20'-difluoro-3',4'- dihydrovinorelbine, de formule (a).

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