Vinca alkaloid antimitotic halogenated derivatives

Details Vinca alkaloid antimitotic halogenated derivatives Vinca alkaloid antimitotic halogenated derivatives

C - Chemistry, Metallurgy

07

D

C07D 519/04 (2006.01) A61K 31/395 (2006.01)

Patent

CA 2286560

The invention concerns novel halogenated derivatives of the vinblastine and vinorelbine family, corresponding to general formula (1) and their therapeutically acceptable salts. The invention also concerns the application of these compounds in therapy and their methods of preparation. The invention further concerns a novel method for preparing vinflunine or 20',20'-difluoro-3',4'-dihydrovinorelbine, of formula (a).

Nouveaux dérivés halogénés de la famille de la vinblastine et de la vinorelbine, correspondant à la formule générale (1) ainsi que leurs sels thérapeutiquement acceptables. L'invention concerne également l'application de ces composés en thérapeutique et les procédés de préparation. L'invention a également pour objet un nouveau procédé de préparation de la vinflunine ou 20',20'-difluoro-3',4'-dihydrovinorelbine, de formule (a).

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