A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/475 (2006.01) A61K 9/127 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2191077
A liposome formulation containing a vinca alkaloid and an anion in an aqueous phase of the liposome. The liposomes also comprise distearoylphosphatidyl choline, cholesterol and distearoylphosphatidylglycerol. A method for enhancing the efficacy and tumor targeting properties of liposomal vinca alkaloid formulations containing unilamellar vesicles.
L'invention concerne une formulation de liposomes contenant un alcaloïde extrait de la pervenche et un anion dans la phase aqueuse des liposomes. Les liposomes contiennent également de la distéaroylphosphatidyle choline, du cholestérol et du distéaroylphosphatidyle glycérol. L'invention concerne également un procédé pour améliorer l'efficacité et la spécificité, vis-à-vis des tumeurs, des liposomes en question constitués de vésicules unilamellaires et contenant un alcaloïde extrait de la pervenche.
Cox Gerry W.
Forssen Eric
Hair Dennis
Nexstar Pharmaceuticals Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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