Vincadifformine synthesis process

C - Chemistry – Metallurgy – 07 – D

Patent

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260/271.3

C07D 471/16 (2006.01) C07C 45/51 (2006.01) C07C 47/14 (2006.01) C07D 209/16 (2006.01) C07D 209/48 (2006.01) C07D 471/04 (2006.01) C07D 471/20 (2006.01)

Patent

CA 1137478

Abstract of the Disclosure: The preparation of vincadifformine and some derivatives thereof for use as a starting material for synthesis of the corresponding vincamine derivatives or for synthesis of bisindole alkaloids having clinically important antitumor properties is described. A .alpha.-methyl tetrahydro .beta.-carboline and a functionnalised aldehyde are condensed to provide in one step the corresponding vincadifformine.

338591

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