Vinyl arenas having retinoid-like activity

Details Vinyl arenas having retinoid-like activity Vinyl arenas having retinoid-like activity

C - Chemistry, Metallurgy

07

D

C07D 333/38 (2006.01) A61K 31/19 (2006.01) A61K 31/33 (2006.01) C07C 63/66 (2006.01) C07C 69/76 (2006.01) C07D 213/80 (2006.01) C07D 215/14 (2006.01) C07D 307/68 (2006.01) C07D 311/58 (2006.01) C07D 311/74 (2006.01) C07D 405/06 (2006.01) C07D 407/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2137819

A process and pharmaceutical compositions for treating several diseases and conditions which are normally treatable with retinoid-like compounds are disclosed where the compounds used for the treatment are substantially non-teratogenic and not ir- ritant to the skin. The process is useful for treating female mammals, including humans, who are pregnant or in the child bearing age. An important partial structural feature of the compounds which provides the non-teratogenic effect and lack of irritation of skin is shown by the formula where the partially drawn ring signifies an aromatic ring which may be carbocyclic or heteroaromat ic, 6-membered or 5-membered, and may be condensed with another ring. R1 is lower alkyl, Cl, Br, or I, R2 is H, lower alkyl, Cl, Br, or I, and R3 is lower alkyl, Cl, Br, I, or is an ether, thioester, ester, thioester, amine or substituted amine group.

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