Vinyl carboxylic acid derivatives, their production and use

Details Vinyl carboxylic acid derivatives, their production and use Vinyl carboxylic acid derivatives, their production and use

C - Chemistry, Metallurgy

07

D

167/228, 260/295

C07D 213/55 (2006.01) C07C 51/363 (2006.01) C07D 201/08 (2006.01) C07D 213/26 (2006.01) C07D 213/30 (2006.01) C07D 213/32 (2006.01) C07D 213/50 (2006.01) C07D 213/57 (2006.01) C07D 405/06 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07F 9/54 (2006.01)

Patent

CA 1246077

Abstract of the disclosure Novel compound of the formula: Image [wherein R1 is a pyridyl group; R2 is a phenyl, thienyl, furyl, naphthyl, benzothienyl or pyridyl group which may have as a substituent a lower alkoxy, a lower alkyl, a halogen, trifluoromethyl, a lower alkenyl or methylenedioxy; R3 is hydrogen, benzyl or a lower alkyl; one of R4 and R5 is hydrogen or a lower alkyl, and the other is an aryloxy, or lower aliphatic hydrocarbon, an alicyclic hydrocarbon having not more than 6 carbon atoms or an aromatic group which may have a substituent, or a group represented by the formula, -S(O)m-R6 (in which R6 is phenyl or a lower alkyl group; m is an integer of 0 to 2), or R4 and R5 each combine with the other to represent one alkylene group; n is an integer of 2 to 6], or a pharmaceutically acceptable salt thereof has a selective inhibitory action on bio-synthesis of thromboxane A2(TXA2) and an effect of enhancing the production of prostaglandin I2(PGI2), and can be used for mammals to prevention and treatment of arterial thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardian infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).

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