Viper venom polypeptides and variants

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

530/7.08, 530/7.

C07K 14/46 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2009390

7273P/ 2/7/89:Fl 17749IB TITLE OF THE INVENTION VIPER VENOM POLYPEPTIDES AND VARIANTS ABSTRACT OF THE DISCLOSURE A platelet aggregation inhibiting polypeptide having the following amino acid seguence: Image wherein X is H or at least one amino acid; Y is OH or at least one amino acid; and each R, either the same or different, is any amino acid. Polypeptides having this sequence are potent inhibitors of fibrinogen binding to receptors expressed on the glycoprotein IIb/IIIa complex in the membrane of platelets, and are therefore potent inhibitors of fibrinogen-induced human platelet aggregation, They are useful in inhibition of platelet aggregation formation.

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