Vipr1s as modifiers of the e2f/rb pathway and methods of use

Details Vipr1s as modifiers of the e2f/rb pathway and methods of use Vipr1s as modifiers of the e2f/rb pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12P 21/06 (2006.01) C40B 30/04 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2664178

Human VIPRl genes are identified as modulators of the E2F/RB pathway, and thus are therapeutic targets for disorders associated with defective E2F/RB function. Methods for identifying modulators of E2F/RB, comprising screening for agents that modulate the activity of VIPRl are provided.

Les gènes VIPR1 humains sont identifiés comme modulateurs de la voie E2F/RB et sont ainsi des cibles thérapeutiques pour des troubles associés à une fonction E2F/RB défectueuse. L'invention concerne des procédés permettant d'identifier des modulateurs de E2F/RB comportant le criblage d'agents qui modulent l'activité de VIPR1.

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