C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/00 (2006.01) C07K 14/02 (2006.01) C07K 14/16 (2006.01) C07K 14/18 (2006.01) C07K 14/435 (2006.01) C07K 16/08 (2006.01) C07K 16/18 (2006.01) C12N 7/04 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2467083
A cell-free method for translation and assembly of viral capsid and capsid intermediates is disclosed. Also disclosed are novel capsid assembly intermediates and novel host proteins which bind to such assembly intermediates. The invention also includes a screening method for compounds that alter viral capsid assembly, and a method of treating viral infection using compounds which inhibit the capsid assembly pathway.
L'invention concerne une méthode acellulaire pour la traduction et pour l'assemblage d'une capside virale et des intermédiaires de capside. L'invention concerne également de nouveaux intermédiaires d'assemblage de capside et de nouvelles protéines hôtes se liant à de tels intermédiaires d'assemblage. L'invention concerne encore une méthode de criblage pour des composés modifiant un assemblage de capside virale, et une méthode de traitement d'infection virale faisant appel à des composés inhibant la voie d'assemblage de capside.
Klein Kevin C.
Lingappa Jaisri R.
Lingappa Vishwanath R.
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
Regents Of The University Of California
University Of Washington
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