Viral chimeras comprised of caev and hiv-1 genetic elements

Details Viral chimeras comprised of caev and hiv-1 genetic elements Viral chimeras comprised of caev and hiv-1 genetic elements

A - Human Necessities

61

K

A61K 39/21 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C07K 14/15 (2006.01) C07K 16/10 (2006.01) C12N 7/01 (2006.01) C12N 15/867 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2330618

The present invention provides a polynucleotide comprising portions of the genomes of caprine arthritis-encephalitis virus and HIV-1, resulting in a chimeric retrovirus referred to as a "CHIV". The invention also provides a vaccine comprising a CHIV immunogen and a pharmaceutically acceptable carrier. A method of stimulating an immune response in an individual against human immunodeficiency virus-1 infection by administering a therapeutically effective amount of a CHIV immunogen is also provided. The invention further provides a method of stimulating an immune response in vitro by contacting a lymphocyte with a therapeutically effective amount of a CHIV immunogen.

L'invention concerne un polynucléotide comprenant des parties des génomes du virus de l'arthrite-encéphalite caprine et de VIH-1, constituant un rétrovirus chimère appelé "VIHC". L'invention porte aussi sur un vaccin comprenant un immunogène de VIHC et un véhicule acceptable au plan pharmaceutique. Une méthode de simulation d'une réponse immunitaire chez un individu, contre l'infection à virus 1 de l'immunodéficience humaine, par l'administration d'une dose efficace au plan thérapeutique d'un immunogène de VIHC, est également décrite. L'invention porte aussi sur une méthode de simulation d'une réponse immunitaire in vitro, par la mise en contact d'un lymphocyte et d'une dose efficace d'un immunogène de VIHC.

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