C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 39/21 (2006.01) A61K 39/245 (2006.01) C07K 14/155 (2006.01) C12N 7/04 (2006.01) C12N 15/86 (2006.01) C12N 15/869 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2091678
A mutant virus for use as a vaccine, wherein the genome of the virus is defective in respect of a gene essential for the pro- duction of infectious virus. In one aspect the mutant virus is capable of protecting a susceptible species immunized therewith against infection by the corresponding wild-type virus. In another aspect, the mutant virus acts as a vector for an immunogenic protein derived from a pathogen and which is encoded by foreign DNA incorporated in the mutant virus. The mutant virus can be produced in a recombinant host cell which expresses a gene complementing the defect. The mutant virus is preferably infec- tious for the host to be protected, but the defective gene allows expression in the infected host of at least some of the viral genes, which can provoke a cell-mediated immune response.
Boursnell Micheal E. G.
Inglis Stephen C.
Minson Anthony C.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cantab Pharmaceuticals Research Limited
Xenova Research Limited
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